Research Interests
The research of this laboratory focuses on the evolution of unicellular microorganisms paying special attention to fungal species. We use comparative genomics, phylogenomics, phylogenetics and synteny based tools to elucidate fungal gene and genome evolution. We are currently using comparative genomics to perform an analysis of 8 Candida and related species, both pathogenic and non-pathogenic, to identify species-specific metabolic pathways and lineage-specific loss or gain of metabolic genes. The presence or absence of particular pathways or pathway components can be correlated with pathogenesis and species-specific virulence characteristics, which can lead to the development of novel therapeutic strategies. We are also investigating the frequency of horizontal gene transfer within the Candida genus. Acquired genetic material from an external source can lead to increased virulence and can provide novel antifungal drug targets. We are also interested in sequencing and annotating medically / biotechnological important fungal strains.